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Spencer is a self-taught artist who began drawing at a young age. Her professional career began in New York City in 1997 working in the fields of advertising and event production. She was a photographer before devoting herself entirely to drawing and painting in 2003 while living in Paris. During this time, Spencer created small works loosely superimposing cartoon-based forms and non-figurative shapes. Influenced by surrealism, cubism and abstract expressionism, this period gave birth to figures and landscapes she would build upon in her later work. The financial crisis in 2008 marked a turning point in Spencer’s art. She began using symbols and content from news sources, reflecting more social, political and cultural themes such as healthcare and different facets of the economic crisis. The presidential campaigns in France and in the United States informed her paintings and the general state of world affairs led to her creating larger compositions, loosening her brushstrokes and exploring more explosive movement, content and color. In 2010, Spencer moved to Chicago, where she currently lives and works.
She is the Founder of Hana Pietri, an artist-run platform, studio, gallery + art production space that champions self-taught and contemporary artists and projects. Spencer is also the co-founder of Latest Acquisition.
Her work is included in many private collections throughout the United States, Europe, Asia and the Middle East.